Bibliometric Analysis of Nursing Interventions to Improve Adherence to Treatment among Patients with Tuberculosis




Bibliometric, nursing intervention, treatment, adherence, tuberculosis, DOTS program


Background: Interest in research on the topic of nursing interventions and medication adherence in tuberculosis (TB) patients has increased. In future research, researchers need information about trends and new things for the topic of nursing intervention research and medication adherence in tuberculosis patients in the future.

Purpose: The purpose of this research is to explore the trend of the number of publications, the trend of the number of citations, the journal with the highest number of publications, network visualisation, overlay visualisation, and density visualisation on the topic of nursing interventions and medication adherence in tuberculosis patients through bibliometric analysis.

Research method: Bibliometric analysis was used in this study. The data is identified through the database, which is then selected using the PRISMA flowchart. Papers are limited to publication in 2018-2023, focusing on the fields of health sciences, nursing, public health, the science of services and health systems, information science, and types of publications are articles. Data were analysed using VOSviewer, and then the analysis results were reviewed by co-occurrence.

Results: A search for publications on nursing interventions to improve medication adherence in TB patients resulted in 60,204 articles. After being filtered through the specified criteria, the number of articles obtained was 3,237. The peak of publications on nursing interventions to improve medication adherence in TB patients occurred in 2018. Meanwhile, the lowest number of publications occurred in 2023. The health sector and other fields such as Human society, Information and computing science, and Psychology carry out research on nursing interventions to improve medication adherence in TB patients. In addition, health trends in nursing interventions to improve medication adherence in TB patients currently focus on using digital technology-based interventions such as mobile health applications, health education, and family support. The density visualisation shows that the topics not widely researched related to nursing interventions to improve medication adherence in TB patients are application, mobile health, health education, family, social support, stigma, and attitude.

Conclusion: The topic of nursing interventions to improve medication adherence in TB patients is a topic that needs to be further developed in various countries. Suggestions for other researchers: please choose a theme included in the visualisation category that has not been widely researched to find novelty for future studies.


Metrics Loading ...


Abebe, A., Nuriye, S., Baza, D., Gelgelu, T. B., Markos, M., and Woldeyohanes, S. 2022. “Experience and Perception of Healthcare Workers on the Challenges of Follow-Up and Treatment of Tuberculosis Patients in Southern Ethiopia: An Exploratory-Descriptive Qualitative Study.” Risk Management and Healthcare Policy 15: 1931–1945. DOI:

Akbar, N., Nursasi, A. Y., and Wiarsih, W. 2020. “Does Self-Stigma Affect Self-Efficacy on Treatment Compliance of Tuberculosis Clients?” Indonesian Contemporary 5 (1): 36–41. http://journal

Al Rasyid, N. H. S., Febriani, N., Nurdin, O. F. T., Putri, S. A., Dewi, S. C., and Paramita, S. 2022. “Tingkat Kepatuhan Minum Obat Pasien Hipertensi Di Puskesmas Lempake Samarinda.” Jurnal Kedokteran Mulawarman 9 (2): 55–63.

Ali, A. O. A., and Prins, M. H. 2019. “Mobile health to improve adherence to tuberculosis treatment in Khartoum state, Sudan.” Journal of Public Health in Africa 10 (2): 1101. DOI:

Alqahtani, S., Kashkary, A., Asiri, A., Kamal, H., Binongo, J., Castro, K., and McNabb, S. 2018. “Impact of Mobile Teams on Tuberculosis Treatment Outcomes, Riyadh Region, Kingdom of Saudi Arabia, 2013-2015.” Journal of Epidemiology and Global Health 7 Suppl 1(Suppl 1): S29–S33. DOI:

Andriani, L., and Prasida, D. W. 2023. “Hubungan Tingkat Pengetahuan dan Dukungan Keluarga dengan Kepatuhan Minum Obat pada Penderita Tuberkulosis di Wilayah Kerja Puskesmas Pahandut.” Jurnal Surya Medika 9 (1). DOI:

Ardat. 2020. “Pengaruh Pengetahuan dan Sikap Terhadap Kepatuhan Minum Obat Pada Penderita TB Paru.” Journal of Pharmaceutical and Health Research 1 (2): 49–53.

Aruan, R. P., Karyadi, T. H., Singh, G., and Rumende, C. M. 2018. “Profil Pasien Lost to Follow-up dan Faktor - Faktor yang Mempengaruhi pada pasien TB-HIV di RSCM.” Indonesia Journal Chest 5 (4): 1–14.

Aryani, L. 2021. “Implikasi Faktor Individu Terhadap Stigma Sosial Tuberkulosis di Kelurahan Tanjung Mas Semarang.” Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo 7 (1): 90. DOI:

Ayana, T. M., Roba, K. T., and Mabalhin, M. O. 2019. “Prevalence of Psychological Distress and Associated Factors among Adult Tuberculosis Patients Attending Public Health Institutions in Dire Dawa and Harar Cities, Eastern Ethiopia.” BMC Public Health 19 (1): 1392. DOI:

Baniqued, M. G., Ballecer, B. A. P., Ballesteros, B. D. C., Balmonte, J. R. R., Bancud, E. M. F., Rebueno, M. C. D. R., and Macindo, J. R. B. 2020. “Social Support from Nurses and Non‐Adherence with Directly Observed Therapy (DOTS) Maintenance Phase among Patients with Tuberculosis in Metro Manila, Philippines.” Public Health Nursing 37 (3): 339–346. DOI:

Bao, Y., Wang, C., Xu, H., Lai, Y., Yan, Y., Ma, Y., Yu, T., and Wu, Y. 2022. “Effects of an mHealth Intervention for Pulmonary Tuberculosis Self-management Based on the Integrated Theory of Health Behavior Change: Randomized Controlled Trial.” JMIR Public Health and Surveillance 8 (7): e34277. DOI:

Chen, X., Du, L., Wu, R., Xu, J., Ji, H., Zhang, Y., Zhu, X., and Zhou, L. 2021. Tuberculosis-related stigma and its determinants in Dalian, Northeast China: a cross-sectional study. BMC Public Health, 21(1), 6. DOI:

Chen, X., Xu, J., Chen, Y., Wu, R., Ji, H., Pan, Y., Duan, Y., Sun, M., Du, L., Gao, M., Wang, J., and Zhou, L. 2021. “The Relationship among Social Support, Experienced Stigma, Psychological Distress, and Quality of Life among Tuberculosis Patients in China.” Scientific Reports 11 (1): 24236. DOI:

Cheng, C.-M., Chang, C.-C., Wang, J.-D., Chang, K.-C., Ting, S.-Y., and Lin, C.-Y. 2019. “Negative Impacts of Self-Stigma on the Quality of Life of Patients in Methadone Maintenance Treatment: The Mediated Roles of Psychological Distress and Social Functioning.” International Journal of Environmental Research and Public Health 16 (7). DOI:

Efendi, S., Sjattar, E. L., and Syam, Y. 2022. “Health Counseling Support Medication Adherence to Regular Pulmonary Tuberculosis Patients.” Clinical Epidemiology and Global Health 15: 101055. DOI:

Efendi, S., Sjattar, E. L., and Syam, Y. 2022. “Model Dan Efek Dukungan Sosial Terhadap Kepatuhan Pengobatan Pasien Tuberkulosis Resisten Obat : a Literature Review.” Jurnal Kesehatan 14 (2): 158. DOI:

Effendy, F., Gaffar, V., Hurriyati, R., and Hendrayati, H. 2021. “Analisis Bibliometrik Perkembangan Penelitian Penggunaan Pembayaran Seluler Dengan Vosviewer.” Jurnal Interkom: Jurnal Publikasi Ilmiah Bidang Teknologi Informasi Dan Komunikasi 16 (1): 10–17. DOI:

Farhana, F., Nurwahyuni, A., and Alatas, S. S. 2022. “Pemanfaatan Digital Health untuk Meningkatkan Keberhasilan Pengobatan Pasien Tuberkulosis di Negara Berkembang.” Media Publikasi Promosi Kesehatan Indonesia (MPPKI) 5 (9): 1043–1053. DOI:

Girsang, Y. B. 2023. “Hubungan Efikasi Diri terhadap Tingkat Kepatuhan Minum Obat pada Pasien Tuberkulosis Paru.” Jurnal Interprofesi Kesehatan Indonesia 2 (2): 274–281. DOI:

Goksu, I. 2021. “Bibliometric Mapping of Mobile Learning.” Telematics and Informatics 56: 101491. DOI:

Gunawan, A. R. S., Simbolon, R. L., Fauzia, D. 2018. “Faktor-Faktor Yang Mempengaruhi Tingkat Kepatuhan Pasien Terhadap Pengobatan Tuberkulosis Paru.” Jom Fk 4 (2): 1–20.

Guix-Comellas, E. M., Rozas-Quesada, L., Velasco-Arnaiz, E., Ferrés-Canals, A., Estrada-Masllorens, J. M., Force-Sanmartín, E., and Noguera-Julian, A. 2018. “Impact of Nursing Interventions on Adherence to Treatment with Antituberculosis Drugs in Children And Young People: A Nonrandomized Controlled Trial.” Journal of Advanced Nursing 74 (8): 1819–1830. DOI:

Habibi, F., Fitriana, A., and Sulityowati, E. 2022. Pemetaan Bibliometrik terhadap Perkembangan Penelitian E-Learning pada Google Scholar Menggunakan Vosviewer. Innovative Education Journal, 4(2). DOI:

Hutajulu, J. 2019. “Hubungan Perilaku dengan Kepatuhan Minum Obat Pada Penderita Tuberkulosis Paru di Puskesmas Helvetia Tahun 2018.” Jurnal Health Reproductive 4 (2): 1–8. DOI:

Jannah, S. R., Husain, F., Iswari, R., and Arsi, A. A. 2021. “Pemanfaatan Mobile Health (mH) Dan Dampaknya Pada Perilaku Kesehatan Mahasiswa Universitas Negeri Semarang (UNNES).” Jurnal Sosiologi Nusantara 7 (1): 181–192. DOI:

Kartika, K., Widyaastuti, E. E., Chaerani, E., and Rossyda, E. N. 2022. “Penerapan Aplikasi Pencegahan Dan Pengobatan TB Paru Di Desa Tanjung Gunung Kabupaten Bangka Tengah.” Jurnal Dimas Binatera 1 (1): 8–12.

Kemenkes, R. I. 2021. “Laporan Program Penanggulangan Tuberkulosis Padang Pariaman.”

Kemenkes R. I. 2020. “Strategi Nasional Penanggulangan Tuberkulosis di Indonesia 2020-2024.” Pertemuan Konsolidasi Nasional Penyusunan STRANAS TB 135.

Kemenkes R. I. 2021. “Cetak Biru Strategi Transformasi Digital Kesehatan 2024. In Kementrian Kesehatan Republik Indonesia.”

Khumairoh, S. (2023). “Hubungan Dukungan Keluarga dengan Kejadian Pemaparan Efek Samping Pengobatan Tuberkulosis Paru di Puskesmas Pekauman Banjarmasin.” Jurnal Citra Keperawatan 11 (1): 34–43.

Kurniyawan, E. H., Noviani, W., Dewi, E. I., Susumaningrum, L. A., and Widayati, N. 2022. “Hubungan Tingkat Stres dengan Efikasi Diri pada Pasien TBC Paru.” Nursing Sciences Journal 6 (2): 55–62.

Latif, A. I., Sjattar, E. L., and Erika, K. A. 2020. “Models and Benefits of Mobile Health Application to Support Patient with Tuberculosis: A Literature Review.” Enfermería Clínica 30: 163–167. DOI:

Latif, A. I., Tiala, N. H., and La, M. 2023. “Tuberkulosis: Tinjauan Medis, Asuhan Keperawatan, dan E-Health. CV.” Ruang Tentor.

Lee, Y., Raviglione, M. C., and Flahault, A. 2020. “Use of Digital Technology to Enhance Tuberculosis Control: Scoping Review.” Journal of Medical Internet Research 22 (2): e15727. DOI:

Letmau, W., Pora, Y. D., and Sadipun, D. K. 2023. “Hubungan Dukungan Keluarga Dengan Kepatuhan Minum Obat Pasien Tuberkulosis Paru Di RSD Kalabahi Kabupaten Alor.” Jurnal Keperawatan Dan Kesehatan Masyarakat 10 (1): 1–9. Unipa/article/view/101 DOI:

Meldawaty, Utami, R. S., and Wulandari, Y. 2023. “Faktor-Faktor Yang Berhubungan Dengan Obat Anti Tuberkulosis (OAT) Dalam Kepatuhan Minum OAT Pada Pasien Tuberkulosis Paru Di Wilayah Kerja UPTD Puskesmas Kabupaten Bintan.” Jurnal Ilmiah Ilmu Keperawatan 14 (1): 199–211.

Minggarwati, R., Juniarti, N., and Haroen, H. 2023. “Intervensi Pada Pasien Tuberkulosis Untuk Meningkatkan Kepatuhan Dan Manajemen Diri.” Jurnal Keperawatan Silampari 6 (2): 1–23. DOI:

Nabila, N. 2023. “Faktor-Faktor yang Mempengaruhi Kepatuhan Minum Obat Anti Tuberkulosis (OAT) pada Penderita Tuberkulosis Paru (TB).” Media Publikasi Promosi Kesehatan Indonesia The Indonesian Journal of Health Promotion 6 (8). DOI:

Nandiyanto, A. B. D., Ragadhita, R., Al Husaeni, D. N., and Nugraha, W. C. 2023. “Research trend on the use of mercury in gold mining: Literature review and bibliometric analysis.” Moroccan Journal of Chemistry 11 (1): 1–19.

Nasution, N., Arwina, H., Nababan, D., and Silitonga, E. 2023. “Dorongan Motivasi Kesembuhan Penderita TB Paru.” Jurnal Ners 7 (2): 993–1004.

Nopiayanti, G., Falah, M., and Lismayanti, L. 2022. “Faktor-Faktor Yang Berhubungan Dengan Tingkat Kepatuhan Minum Obat Pada Penderita Tb Di Kota Tasikmalaya.” Healthcare Nursing Journal 4 (1): 243–247. DOI:

Nurmala, I., Rahman, F., Nugroho, A., Erlyani, V., Laily, N., Anhar, V. Y. 2018. “Promosi Kesehatan.” Pusat Penerbitan dan Percetakan Universitas Airlangga (AUP) (RK), 2018. Promosi Kesehatan.pdf

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S, Moher, D. 2021. “The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews.” BMJ (Clinical Research Ed.) 372: n71. DOI:

Pampalia, N., and Waluyo, A. 2019. “M-Health Untuk Kepatuhan Pasien TB Dalam Pengobatan.” Jurnal Wacana Kesehatan 4: 404. DOI:

Pasaribu, G. F., Handini, M. C., Manurung, J., and Manurung, K. 2022. “Ketidakpatuhan Minum Obat Pada Pasien TB Paru : Studi Kualitatif.” Jurnal Prima Medika Sains 5 (1): 48–56.

Pramono, J. S., and Wiyadi, W. 2021. “Hubungan Lingkungan Fisik Rumah dan Kepadatan Hunian dengan Prevalensi Tuberkulosis di Kecamatan Sungai Kunjang Kota Samarinda.” Jurnal Kesehatan Masyarakat Indonesia 16 (1): 42. DOI:

Purba, S. K. R., and Manihuruk, F. N. 2023. “Analisa Mycobacterium Tuberculosis Pada Penderita Diabetes Melitus Di RSUD Dr. R. M. Djoelham Binjai Sanna.” HIJP : Health Information Jurnal Penelitian 15 (2): 58–66.

Ratnasari, N. Y. 2023. “Upaya Peningkatan Pengetahuan Melalui Pemberian Penyuluhan Kesehatan Tentang Penatalaksanaan Tuberkulosis Pada Kelompok Lansia ‘Ngudi Waras .’” Jurnal Abdiman Pamenang-JAP 1 (1): 49–54. DOI:

Roslaini, S. 2023. “Stigma Factors in Pulmonary TB Patients In North Aceh District.” Jurnal Kesehatan Akimal 2 (1): 8–15. DOI:

Rumaolat, W. 2022. “Peningkatan Kepatuhan Minum Obat Tuberkulosis Paru Melalui Pendidikan Kesehatan Berbasis Media Visual.” Jurnal Penelitian Kesehatan Suara Forikes 13 (7): 575–579.

Saidi, S. S., and Abdul Manaf, R. 2023. “Effectiveness of Family Support Health Education Intervention to Improve Health-Related Quality of Life Among Pulmonary Tuberculosis Patients in Melaka, Malaysia.” BMC Pulmonary Medicine 23 (1): 139. DOI:

Sekandi, J. N., Buregyeya, E., Zalwango, S., Dobbin, K. K., Atuyambe, L., Nakkonde, D., Turinawe, J., Tucker, E. G., Olowookere, S., Turyahabwe, S., and Garfein, R. S. 2020. “Video Directly Observed Therapy for Supporting and Monitoring Adherence to Tuberculosis Treatment in Uganda: A Pilot Cohort Study.” ERJ Open Research 6 (1). DOI:

Septiani, D., Haniifah, F. N., Riswaluyo, M. A., and Anwar, N. M. 2022. “Penggabungan Aplikasi Telemedicine TB Sebagai Optimalisasi Pelayanan TB Selama Masa Pandemi COVID-19 Merging TB Telemedicine Application as Optimising Tuberculosis Health Care During COVID-19 Pandemic.” Bikfokes 2 (2): 117–125. DOI:

Wagania, F. F., Kandou, G. D., and Wungouw, H. I. S. 2023. “Monitoring Pengawasan Menelan Obat ( PMO ) Berbasis Audio Visual Terhadap Kepatuhan Pengobatan Pasien Multi Drug Resisten Tuberculosis ( MDR-TB ) Di Sulawesi Utara.” Jurnal Kesehatan Tambusai 4 (2): 1117–1126.

WHO. 2022. “Global Tuberculosis Report 2022.” WHO, 2022.

Ximenez, H. M., Arief, Y. S., Ulfiana, E., and Hasanudin, H. 2022. “Efektivitas Terapi Video Directly Observed Therapy (VDOT) Dibandingkan dengan Directly Observed Therapy (DOT) dalam Meningkatkan Kepatuhan Minum Obat pada Pasien TB.” Journal of Telenursing (JOTING) 4 (2): 750–757. DOI:




How to Cite

Aisah, Siti, Much Nurkharistna Al Jihad, Audia Pebriani, Satriya Pranata, and Edy Soesanto. “Bibliometric Analysis of Nursing Interventions to Improve Adherence to Treatment Among Patients With Tuberculosis”. Africa Journal of Nursing and Midwifery, 19 pages.



Review Article
Received 2023-09-01
Accepted 2023-11-09
Published 2024-01-26